We further examined the effect of the KSRP-NEDD4L axis in regulating ccRCC progression in a ccRCC-bearing mouse model through orthotopically injecting luciferase-expressing Caki-1 cells (Caki-1-shCtrl-luciferase, Caki-1-shKSRP-luciferase, Caki-1-shNEDD4L-luciferase, or Caki-1-shKSRP/shNEDD4L-luciferase) into NOD-SCID mice. The gene discussed is NEDD4L; the disease is nonpapillary renal cell carcinoma.