Combining information from The Cancer Genome Atlas (TCGA)-Kidney Renal Clear Cell Carcinoma (KIRC) database with the results of miRNA and complementary (c)DNA microarrays, we identified the E3 ubiquitin ligase, neural precursor cell-expressed developmentally downregulated 4 like (NEDD4L), as a novel target of KSRP which can reverse KSRP-promoted ccRCC progression in vitro and in vivo. Here, KHSRP is linked to nonpapillary renal cell carcinoma.