The same aforementioned TCGA-KIRC and E-MTAB-1980 datasets all indicated that ccRCC patients with KSRPhigh/NEDD4Llow had the worst prognoses (OS or DSS) compared to those with KSRPlow/NEDD4Lhigh or other expression statuses (Fig. 3J), and these clinical data further confirmed that upregulation of KSRP and downregulation of NEDD4L are critical events in promoting ccRCC progression. The gene discussed is NEDD4L; the disease is nonpapillary renal cell carcinoma.