In the study on the pathogenesis of nasopharyngeal carcinoma (NPC), it was found that Epstein-Barr virus (EBV) plays a vital role as the prominent oncogene encoded by EBV, latent membrane protein 1 (LMP1),which inhibits LKB1-AMPK activity through ERK-MAPK activated by CTAR1 domain of LMP1 [83]. This evidence concerns the gene STK11 and nasopharyngeal carcinoma.