Meanwhile, it was found that the benzopyran derivative 2-imino-6-methoxy-2H-chromene-3-carbothioamide (IMCA) induced ferroptosis in colorectal cancer (CRC) by activating the AMPK signaling pathway and inhibiting the mTOR/p70S6k signaling pathway activity, downregulation of SLC7A11 expression and reduce of Cys and glutathione, ultimately leading to ROS accumulation and ferroptosis [91]. Here, SLC7A11 is linked to colorectal cancer.