CRY1 deficiency led to glucose intolerance and high levels of circulating corticosterone which indicates a decrease in the suppression of the hypothalamic-pituitary-adrenal (HPA) axis along with improved glucocorticoid transactivation in the liver [43, 47].On the other hand, an AHEI includes components such as fruits, vegetables, and unsaturated fatty acids that can have positive effects on fat and glucose metabolism [48–51]. Here, CRY1 is linked to Glucose intolerance.