Since, PI3K/AKT has a key role in promotion of EMT process, it can be expected that the clinical monoclonal antibodies such as Cetuximab and Panitumumab that can target the RTKs as the main triggers of this pathway can be used as the indirect EMT inhibitors to reduce the CRC metastasis and improve prognosis among these patients. Here, AKT1 is linked to colorectal carcinoma.