NPPB and pulmonary arterial hypertension: As shown in Table 2, many patients with PAH had severe cardiac involvement at PAH diagnosis, with a median PASP of 67.0 (interquartile range 48.5–90.0) mmHg and a median level of BNP of 180.0 (interquartile range 63.8-478.5) pg/mL.