CCR7 and Cognitive impairment: Preventing the lymphatic drainage of CNS/meningeal derived antigens, and trafficking of leukocytes into/out of the cervical LNs, either by surgical ligation of the afferent lymphatics to the deep cervical LNs (or resection of the same LNs), treatment with the sphingosine-1-phosphate receptor modulator FTY720, or deficiency in CCR7 expression, have been linked to altered meningeal T cell responses and the development of cognitive deficits [18, 21, 37, 74, 86].