TREM2 and Mental deterioration: Data obtained with either Trem2–/– or humanized TREM2R47H-expressing mice (that also causes TREM2 loss-of-function) seem to suggest that the TREM2-dependent DAM phenotype is protective when it comes to constraining Aβ plaques, preventing the spread of toxic Aβ species, and averting neuronal death and cognitive decline [134, 158–161].