Interestingly, loss of hematopoietic CCR7 in adult mice was enough to recapitulate the increased numbers of both effector (IFN-γ-producing) and Tregs in the dura that is seen in old mice, as well as the reduction in glymphatic influx of CSF and an early appearance of cognitive deficits [37, 39]. The gene discussed is CCR7; the disease is Cognitive impairment.