TLR4 and Insulin resistance: For patients with DN, higher uric acid levels are associated with higher microalbuminuria, lower eGFR [52]; Linoleic acid would ameliorate hyperuricemia, insulin resistance and renal inflammation, accompanied with the downregulation of renal GLUT9 and URAT1 in fructose-fed rats and the inhibition of NLRP3 inflammasome and TLR4/MyD88 signaling [53]; Tyrosine metabolism is correlated with multiple diseases such as fatty liver, insulin resistance, and obesity [54].