KEGG analysis showed the relevant signaling pathways for SIN treating DN include lipid and atherosclerosis, IL-17 signaling pathway, AGE-RAGE signaling pathway in diabetic complications, NOD-like receptor signaling pathway, TNF signaling pathway, JAK-STAT signaling pathway, type II diabetes mellitus, etc. (Fig. 2G). The gene discussed is TNF; the disease is type 2 diabetes mellitus.