KEGG analysis showed the relevant signaling pathways for SIN treating DN include lipid and atherosclerosis, IL-17 signaling pathway, AGE-RAGE signaling pathway in diabetic complications, NOD-like receptor signaling pathway, TNF signaling pathway, JAK-STAT signaling pathway, type II diabetes mellitus, etc. (Fig. 2G). This evidence concerns the gene RENBP and atherosclerosis.