Moreover, chromatin accessibility profiling of leukemia cells disrupted for cBAF (Smarcd2 knockout), MLL1 (Kmt2a knockout) or MLL4 (Kmt2d knockout) showed that these chromatin factors are required to maintain optimal accessibility at the Stat5a and Runx2 binding loci (Fig. 6d,e and Extended Data Fig. 10f). This evidence concerns the gene RUNX2 and leukemia.