AHCY and colorectal carcinoma: We analysed publicly available transcriptomic data from The Cancer Genome Atlas (TCGA; PanCancer Atlas) to understand which enzymes of the methionine cycle are transcriptionally regulated in human CRC, and found increased AHCY (adenosylhomocysteinase or SAH hydrolase) expression in colorectal adenocarcinoma compared to normal colon tissue (Fig. 3d).