In relation to this, MT2A is considered a key player in the maintenance of immune homeostasis (Jakovac et al., 2013) and its involvement as a neuroprotective factor has been described in different neurodegenerative diseases such as Parkinson's disease (Miyazaki et al., 2013), Alzheimer's disease (Chung et al., 2010), or amyotrophic lateral sclerosis (Brandebura et al., 2023). The gene discussed is MT2A; the disease is early-onset autosomal dominant Alzheimer disease.