HSPA8 inhibitors have attracted intensive studies for treatment of cancer and autoimmune diseases, but such efforts were hindered by their side effects such as their toxicity to normal tissues.35,36 To test whether RIP3-dependent necroptosis contributes to the adverse effects of HSPA8 inhibitors, we treated the WT and Rip3−/− mice with HSPA8 inhibitor Pifithrin-μ (PES) or Apoptozole (AZ). This evidence concerns the gene HSPA8 and autoimmune disease.