Even after 30 days of co-incubation, HSPA8 alone cannot disaggregate the unfolded Parkinson’s disease-linked presynaptic protein α-synuclein (α-syn) fibrils.39,40 Surprisingly, after incubation with HSPA8, the RIP3 fibrils were quickly dismantled into a small globular structure representing small RIP3 oligomers disassembled from the mature fibrils, as shown in EM images in Fig. 4a. This evidence concerns the gene HSPA8 and Parkinson disease.