AIFM2 and cancer: Besides iron and ROS, ferroptosis is regulated by other pathways such as the p53 pathway in cancer, it can be suppressed by several pathways including ferroptosis suppressor protein 1 (FSP1)-CoQ10 pathway [6, 7], GCH1-BH4 pathway [8], and the DHODH-CoQH2 system [9, 10] (Fig. 1).