The authors prove that the manganese (Mn2+) treatment-induced tumor cell death is irrelevant to the apoptosis, necroptosis, pyroptosis or autophagy, but only to ferroptosis, in which type I interferons (IFNs) were the main mediators of downregulated DHODH expression and subsequent mitochondrial ROS accumulation; however, the expression of components in other ferroptosis pathways, such as the GPX4, FSP1-CoQ10, and GCH1-BH4 pathways, remained unchanged [141]. The gene discussed is DHODH; the disease is neoplasm.