For instance, AMPD3 is known to be highly expressed in gastrointestinal stromal tumors19; BGLAP is expressed in pancreatic cancer cells and promotes their growth and invasion20; COL6A6 inhibits the growth of non-small cell lung cancer21; PODN inhibits the growth of osteosarcoma22; and SOD3 is downregulated in breast cancer23. This evidence concerns the gene SOD3 and familial pancreatic carcinoma.