C-ZF mutations impact GATA2 DNA-binding affinity at different levels: L359V (CML) shows increased affinity31, R362Q (AML) has modest to no impact in binding affinity, T354M and R398W (AML/MDS) show moderate reduction in affinity to DNA and the ES mutations R361L, C373R and R396Q result in little to no DNA binding, as evaluated by EMSA28,30. Here, GATA2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.