GATA2 and acute myeloid leukemia: C-ZF mutations impact GATA2 DNA-binding affinity at different levels: L359V (CML) shows increased affinity31, R362Q (AML) has modest to no impact in binding affinity, T354M and R398W (AML/MDS) show moderate reduction in affinity to DNA and the ES mutations R361L, C373R and R396Q result in little to no DNA binding, as evaluated by EMSA28,30.