The most common reasons for interruptions of apatinib were hypertension (19 [38.8%]), hand and foot syndrome (15 [30.6%]), increased aspartate aminotransferase (nine [18.4%]), and increased alanine aminotransferase (eight [16.3%]); similarly, increased aspartate aminotransferase (nine [18.4%]) and increased alanine aminotransferase (eight [16.3%]) led to camrelizumab interruptions. This evidence concerns the gene GPT and hypertensive disorder.