For instance, bisphosphonates have been reported to have higher fracture rates after long-term use, characterized as more than six years and requiring a “bisphosphonate holiday”.74 RANKL antibodies have been reported to have some side effects, such as skin eczema, flatulence, cellulitis, and osteonecrosis of the jaw.75 Thus, there is still a need for osteoporosis treatment. Here, TNFSF11 is linked to osteoporosis.