Organoids also expressed proteins involved in congenital anomalies of the kidney and urinary tract (CAKUT), proteins related to metabolic diseases such as Fanconi syndrome (using the expressed HNF4A nuclear hormone receptor), several metabolic storage diseases (M. Fabry, Galactosemia, GM1-Gangliosidosis, McArdle disease, Niemann-Pick disease), as well as proteins related to cystinosis47 immunodeficiency, porphyria and hyperoxaluria. This evidence concerns the gene HNF4A and metabolic disease.