To assess whether overexpression of HDGF ameliorates HD phenotypes in vivo, we performed stereotactic injections of AAV8-EYFP-P2A-Flag-HDGF or AAV8-EYFP control virus into the dorsal striatum of 4-wk-old R6/2 mice and WT littermates (Fig S5A). The gene discussed is HDGF; the disease is Huntington disease.