In addition to the early-onset transgenic R6/2 model, which expresses an N-terminal fragment of mHTT, we investigated the consequences of HDGF overexpression in the late-onset zQ175DN knock-in mouse model (Menalled et al, 2012; Southwell et al, 2016) that expresses full-length mHTT from the endogenous murine Htt locus and, therefore, more faithfully reproduces human HD. This evidence concerns the gene HTT and Huntington disease.