HDGF and Huntington disease: To test whether HDGF is neuroprotective in the context of HD, we first used an inducible stable neuron-like PC12 cell line with pathologically expanded HTT-exon1-Q74 fused to EGFP and a control PC12 cell line with non-pathogenic HTT-exon1-Q23–EGFP (Fig 1A) (Wyttenbach et al, 2001).