PLOD1 and Hypergonadotropic hypogonadism: Therefore, similar to humans, the results ofhormonal tests in the present study indicate that nicotine injection in mice maycause primary hypogonadism in these animals following the decrease of testosteroneand increase of LH, and the use of corn silk aqueous and methanol extractsneutralize this change and protect the testicle from inducing such a disorder.Finally, by using the results of the present fundamental-experimental study, it ispossible to understand the effects of corn silk extract on the male reproductivesystem.