PLOD1 and Hypergonadotropic hypogonadism: In conclusion, the results of the present study showed that the consumption ofnicotine led to increased MDA and decreased GSH in the testicles of treated animals,and subsequently, by creating oxidative stress in this organ, it had a reducingeffect on the serum testosterone level and sperm count, and increased LH levels.These changes can indicate the induction of primary hypogonadism in small laboratorymice, and we require more studies in this field.