MAPT and Alzheimer disease: Analysis of baseline FTP SUVR contrast maps (Figure 1A) noted increased tau burden in A− TMTL+ individuals to be most pronounced in the MTL and extending into the inferior temporal lobe and the ventromedial prefrontal cortex, while A+ TMTL+ individuals showed the AD-characteristic pattern of widespread cortical tau accumulation across temporal, parietal, and frontal areas.