NR3C2 and plasma cell myeloma: We first examined whether GCs regulate MR mRNA and protein levels (Fig. 1A, B) in five myeloma cell lines (MM1.S, OPM-2, L-363, U-266 and MM1.R) [34, 35] with different sensitivities to Dex-mediated myeloma cell killing (Fig. 1C).