Taken together, our transcriptome analysis and subsequent validation at the protein level reveals that gene transcription is halted more strongly by Dex-Spi than by Dex alone in MM cells, with c-myc, cyclinD1, REDD1 and BOB-1 being strongly Dex-Spi-downregulated targets. This evidence concerns the gene POU2AF1 and Miyoshi myopathy.