The commonest genes associated with nephrotic syndrome differ at birth (NPHS1, NPHS2, WT1, LAMB2, PAX2, PLCE1), in childhood or adolescence (NPHS1, NPHS2, WT1, LAMB2, SMARCAL1, NUP107, TRPC6, PLCE1) and in adults (COL4A3-COL4A5, GLA, ACTN4, CD2AP, INF2, TRPC6). This evidence concerns the gene PLCE1 and nephrotic syndrome.