The commonest genes associated with adult-onset FSGS (COL4A3, COL4A4, COL4A5) have ocular abnormalities as does GLA (Fabry disease), but not ACTN4, CD2AP, INF2 or TRPC6. LMX1B and MYH9 are infrequent causes of FSGS but ocular features are common. This evidence concerns the gene COL4A5 and Fabry disease.