Across bulk Ovarian Cancer tumour data sets, which included epithelium and stroma, three of six independent data sets showed decreased PTEN mRNA in Tumour versus Normal samples, with nonsignificant data sets all possessing a low number of normal samples (n = 4–6; Fig 1D; Wu et al, 2007a; Data ref: Wu et al, 2007b; Bonome et al, 2008a; Data ref: Bonome et al, 2008b; King et al, 2011a; Data ref: King et al, 2011b; Elgaaen et al, 2012a; Data ref: Elgaaen et al, 2012b; Hill et al, 2014a; Data ref: Hill et al, 2014b; Yamamoto et al, 2016a; Data ref: Yamamoto et al, 2016b). This evidence concerns the gene PTEN and neoplasm.