In contrast, ARF6 showed a less consistent alteration across data sets, with ARF6 mRNA elevated in only three of seven bulk tumour data sets, and ARF6 mRNA elevation occurring in the stroma in LCM data sets (Fig 6H–J; Appendix Fig S2G–L) (Data refs: Wu et al, 2007b, Bonome et al, 2008b, Bowen et al, 2009b, King et al, 2011b, Elgaaen et al, 2012b, Lili et al, 2013b, Yeung et al, 2013b, Hill et al, 2014b, Yamamoto et al, 2016b). The gene discussed is ARF6; the disease is neoplasm.