The persistence of mutated <i>NPM1</i> or <i>FLT3</i>-ITD in the blood of adult patients with AML in first complete remission (CR1) prior to allogeneic hematopoetic cell transplant (alloHCT) has been established as associated with increased relapse and death after transplant. This evidence concerns the gene NPM1 and acute myeloid leukemia.