IL1A and septic shock: Inflammatory markers IL-8, HSP70, CCL3, CCL4, GZMB and IL-1a were higher among patients with the PHES phenotype vs. other septic shock patients (p<0.05, Supplemental Digital Content, Figure 1). The endothelial markers sTM, Angpt-2, Angpt-2/Angpt-1, Angpt-2/Tie-2, and ICAM-1 were also higher among patients with PHES phenotype vs. other septic shock patients (p<0.05, Supplemental Digital Content, Figure 2).