To identify Hh target genes underlying these phenotypes, differentially expressed Hh target genes from NIH3T3 cells (Fig. 1 and Supplementary Table 3) were compared to differentially expressed genes from (1) RNA sequencing of 250 Hh-associated medulloblastomas compared to 208 Group 3 medulloblastomas from humans21–23 (Fig. 4a and Supplementary Table 5), or (2) RNA sequencing of Math1-Cre SmoM2c genetically engineered mouse models of Hh-associated medulloblastoma (n = 3) compared to age-matched control cerebella from SmoM2c mice (n = 3)17 (Fig. 4b and Supplementary Table 6). The gene discussed is ATOH1; the disease is medulloblastoma.