HSD11β1 overexpression attenuated Hh-associated medulloblastoma tumorigenesis (3 of 12 mice, 25%) compared to Retnla overexpression (12 of 13 mice, 92%) or NESMYCN control cells without overexpression of Hh target genes (24 of 25 mice, 96%) (Fig. 5d). This evidence concerns the gene HSD11B1 and medulloblastoma.