HSD11B1 and medulloblastoma: To elucidate the gene expression programs underlying phenotypic differences across iPSC-derived NESMYCN Hh-associated medulloblastomas, RNA sequencing was performed on control tumors (n = 3), tumors with HSD11β1 overexpression (n = 3), and tumors with Retnla overexpression (n = 3) (Supplementary Table 7).