SMO and skin basal cell carcinoma: Lipidomic mass spectrometry on the same 10 pairs of matched BCC and adjacent skin samples showed enrichment of cilia-associated and Smo-activating sterols and oxysterols in BCC compared to adjacent skin, including cholesterol, desmosterol, 7-keto,27-hydroxycholesterol (7k,27-OHC), 24k-cholesterol (24k-C), and 24(S),25-EC10 (Fig. 3a).