Differential expression and ontology analyses demonstrated enrichment in cell signaling and cell adhesion programs in medulloblastomas with overexpression of Retnla, and suppression of ciliary organization and Hh cell fate programs (e.g. endochondral ossification) in medulloblastomas with overexpression of HSD11β1 (Fig. 5g). The gene discussed is HSD11B1; the disease is medulloblastoma.