In support of this hypothesis, comparison of differentially expressed genes in human BCC (Fig. 2 and Supplementary Table 4) to differentially expressed Hh target genes in NIH3T3 cells (Fig. 1 and Supplementary Table 3) revealed Hsd11β1 was suppressed but canonical Hh target genes (Gli1, Ptch1) were enriched in human BCC (Fig. 3b). The gene discussed is PTCH1; the disease is skin basal cell carcinoma.