KDR and metastatic malignant neoplasm in the lymph nodes: Moreover, expression of VEGFR2 associated with the extent of lymph node metastasis, pN2-3 versus pN0 (p = 0.0007) and pN2-3 versus pN1 (p = 0.030) (Fig. 2d) and with presence of metastasis versus M0 (p = 0.0412) (Supplementary Fig. 2a).