On the other hand, we found only moderate correlation between NfL-c and NfL-p consistent with previous reports for neurodegenerative disorders.20, 26 The probably most compelling explanation for this lies in the fact that axonal degeneration in MSA is predominantly a central process and NfL elevation in plasma therefore mostly the result of spill-over across the blood-brain barrier. The gene discussed is NEFL; the disease is multiple system atrophy.