NEFL and peripheral neuropathy: Since that barrier is furthermore known to be more “leaky” in MSA, another element of variability is added.40 On the other hand, NfL-p is also known to be elevated in peripheral neuropathies indicating a peripheral contribution to plasma NfL.41, 42 One may therefore expect to see transient elevations as a result of falls and other injuries resulting in soft tissue damage, which are common in MSA, particularly since the levels of NfL in plasma are very low.