Patients with autosomal dominant (AD) or autosomal recessive (AR) hyper-IgE syndrome due to dominant-negative variants of STAT3 or IL6ST or biallelic variants of ZNF341 (6–12), AD STAT1 gain-of-function (13–17), AD JNK1 deficiency (18), or AR deficiencies of IL-12p40, IL-12Rβ1, IL-23R (6, 19–21), CARD9 (22–24), or RORγT (25) present with CMC as one of the main infectious manifestations, with complications due to susceptibility to other pathogens, autoimmune manifestations, and/or cancers (4, 26). This evidence concerns the gene MAPK8 and Alzheimer disease.