IL-17A and IL-17F (IL-17A/F) binding to their receptors results in recruitment of ACT1, an adapter molecule activating several downstream signaling pathways (35, 38), to the cytoplasmic domains of the receptors, leading to release of antimicrobial peptides and cytokines/chemokines such as IL-6, G-CSF, CXCL1 and CXCL8 to control Candida infection. This evidence concerns the gene IL17A and candidiasis.