In addition, inflammation and the pathophysiology of DN involve complex signaling pathway activation (Bui et al., 2020), such as NF-κB pathway, The janus kinase/signal transducers and activators of transcription (JAK–STAT) pathway and nod-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome pathway. The gene discussed is NFKB1; the disease is liver dysplastic nodule.