INS and liver dysplastic nodule: A randomized clinical study demonstrated that a mixture of Lactobacillus acidophilus, Bifidobacterium bifidum, Lactobacillus reuteri and Lactobacillus fermentum effectively increased insulin sensitivity and ameliorated glycemic control in patients with DN (Mafi et al., 2018), the similar effects were observed by probiotic Bacillus coagulans T11honey consumption in DN patients (Arani et al., 2019).