APOE and Alzheimer disease: There are significant changes in the magnitude of predictive risk – one standard deviation increase in the MetaGRS is associated with about 26% increase in the AD risk (HR = 1.259, p = 1.45E-15, Supplementary Table 3), compared to an increase of 57% when APOE region is included in the calculation of AD GRS (HR = 1.577, p = 7.17E-15, Table 2).