In addition, the P2X7/NLRP3 pathway plays an essential role in amplifying inflammation via an ATP feedback loop, thus promoting the inflammatory response; however, the function of the P2X7 receptor is not fully understood, but it is involved in ATP-induced apoptotic death in hemopoietic and CLL cells [81]. This evidence concerns the gene P2RX7 and B-cell chronic lymphocytic leukemia.