NLRP3 and acute myeloid leukemia: In this study, an imbalance of T-helper lymphocyte subpopulations with an increase in the Th22 profile and a decrease in Th1 in de novo AML patients was also observed, which leads us to think that NLRP3, together with AHR, may cooperate in the development of AML and influence the T lymphocyte differentiation [74].