In general, in leukemias, IL-1β has been associated with (i) increased proliferation of leukemic cells [24–28] and (ii) recruitment of myeloid-derived suppressor cells (MDSCs) to the TME through the upregulation of the NF-κB pathway, which promotes immunosuppression and favors the survival of the leukemic clone [29, 30]. The gene discussed is IL1B; the disease is leukemia.