During the intense immune response caused by an infection, for example, the proinflammatory cytokines IL-6, TNF-α, and IL-1β cooperate with MSCs to create a favorable niche for preleukemic cells by which there is the secretion of CXCR2 ligands that attract preleukemic cells (e.g., ETV6::RUNX1+) activin (ACTA)-dependents [18, 19]. Here, IL1B is linked to infection.