Notably, of the top 100 exosomal proteins reported by ExoCarta (25), 8 (CD63, RAB14, VCP, BSG (a.k.a. CD147), FLNA, GNAI2, LAMP2, EZR) were significantly upregulated at the protein level in the T1D group. The gene discussed is CD63; the disease is type 1 diabetes mellitus.