Obesity, is associated with increased secretion of pro-inflammatory factors (as described in Figure 1)) that may be harmful to bone and activation peroxisome proliferator-activated receptor-γ (PPARγ) and CCAAT/enhancer-binding protein alpha (CEBPa), nuclear factor kappa light chain enhancer of activated B cells (NF-Kb) pathway (17, 18). The gene discussed is CEBPA; the disease is obesity due to melanocortin 4 receptor deficiency.