Among eight cancer cell lines with TP53 mutations (not including TP53-null cell lines), H1437 cells were much less responsive to the cytostatic/cytocidal effects of 4SP65 with significantly higher values observed for each dose-response metric compared to other TP53 mutant cancer cell lines (P-values of 2 × 10-7 for GI50s to 6 × 10-6 for LC99s). Here, TP53 is linked to cancer.