One SHH tumor was found to have a TERT promoter mutation (C228T, MDT-AP-3724) as well as a previously described CREBBP mutation (p.R1446L c.4337G>T), a single-base deletion in exon 34 of lysine-specific methyltransferase 2D (KMT2D), an interchromosomal translocation between chromosomes 3 and 14 (Supplemental Figure 4A), 4 copies of 3q and loss of 14q24.1-q32.33 (Supplemental Figure 4B). The gene discussed is CREBBP; the disease is neoplasm.