In the G4 medulloblastomas, SVs affecting GFI1 and GFI1B and the recurrent tandem duplication of SNCAIP are known to cause overexpression of GFI1, GFI1B and PRDM6, respectively, by putting them under the control of super-enhancer regions (termed enhancer hijacking, EH). The gene discussed is GFI1B; the disease is medulloblastoma.