CREBBP and medulloblastoma: Additionally, analysis of the linked-red data allowed us to detect two mutations in KDM6A, a frameshift variants in KMT2D [known to be recurrently mutated in G4-MB (10)], a mutation in CREBBP annotated as likely pathogenic in ClinVar, and a second TERT promoter mutation (C228T).KDM6A is a lysine demethylase recurrently mutated in both G3 and G4 medulloblastomas (36).