PLCB1 and breast cancer: It was found that PLC-β1 could hydrolyze PI(4,5)P2 to produce IP3 and DAG, which targeted to reduce the level of PI(4,5)P2 in plasma membrane, which made PI(4,5)P2 binding protein cofilin released into cytoplasm from its inactive membrane association state, thereby increasing actin in breast cancer cells to promote cell migration activity.