However, the high expression of PLC-β2 in low-invasive tumor cells can also prevent the malignant progression related to hypoxia (59), that is, PLC-β2 can increase the level of E-cadherin in cells, block the up-regulation of CD133, and induce the adhesion of tumor cells to reduce their metastasis and invasion activity, thus preventing the progression of breast malignant tumors (Figure 3) (57). Here, PLCB2 is linked to breast cancer.