LPA and malignant colon neoplasm: In addition, LPA, through its homologous receptors (LPAR1-LPAR6), can produce a variety of cellular responses with the cooperation of PLC-β signals (32, 33), for example, LPAR2 stimulates the proliferation and migration of colon cancer cells, while the deletion of LPAR2 can inhibit the progress of colon cancer (34, 35).