It was found that ORP4L transported PLC-β3 out of the nucleus of leukemia cells, and regulated PIP2 metabolism and downstream Ca2+ balance by forming ORP4L/Gαq/11/PLC-β3 complex, further regulating pyruvate dehydrogenase activity on mitochondria to provide oxidative phosphorylation energy for leukemia cells. Here, PLCB3 is linked to leukemia.