Therefore, PLC-β1a also exists in the cytoplasm, while PLC-β1b mainly exists in the nucleus (94).PLC-β1a is a negative regulator of erythroid differentiation, and which is reduced in erythropoietin-responder MDS patients and in normal hematopoietic stem cell progenitors induced to erythroid differentiation (95). The gene discussed is PLCB1; the disease is myelodysplastic syndrome.