In addition, LPA, through its homologous receptors (LPAR1-LPAR6), can produce a variety of cellular responses with the cooperation of PLC-β signals (32, 33), for example, LPAR2 stimulates the proliferation and migration of colon cancer cells, while the deletion of LPAR2 can inhibit the progress of colon cancer (34, 35). Here, LPAR6 is linked to malignant colon neoplasm.