PLCB2 and neoplasm: However, the high expression of PLC-β2 in low-invasive tumor cells can also prevent the malignant progression related to hypoxia (59), that is, PLC-β2 can increase the level of E-cadherin in cells, block the up-regulation of CD133, and induce the adhesion of tumor cells to reduce their metastasis and invasion activity, thus preventing the progression of breast malignant tumors (Figure 3) (57).