CXCR2, PLC-β3 and Na+/H+ exchanger regulatory factor-1 (NHERF1) form macromolecular complexes on the plasma membrane of pancreatic cancer cells, which functionally couples the signal cascade mediated by CXC chemokine and PLC-β3 (45). The gene discussed is NHERF1; the disease is familial pancreatic carcinoma.