It was proven that through the administration of DHI to rats with bile duct ligation‐induced liver fibrosis for 14 days, YAP lost the ability to bind to TEAD in the cell nucleus so the mRNA expression of its downstream profibrotic gene, such as TGFβ1, α‐SMA and COL1A1 and collagen deposition all decreased.268. The gene discussed is YAP1; the disease is Hepatic fibrosis.