Furthermore, Rac‐GTPase, a member of the Rho‐GTPase family, was shown to activate YAP/TAZ in a model of renal fibrosis, and at the same time, Rac‐GTPase also mediated the production of free radicals that contributes to the phosphorylation and activation of EGF receptor (EGFR).304. This evidence concerns the gene YAP1 and renal fibrosis.