In addition, in mice with unilateral ureteral obstruction (UUO)‐induced renal fibrosis, YAP/TAZ deficiency can also reduce endothelial–mesenchymal transition, ECM deposition, and fibroblast‐myofibroblast transdifferentiation and finally improve renal interstitial fibrosis.292, 293. This evidence concerns the gene YAP1 and renal fibrosis.