In osteosarcoma, the increased expressions of S1P and its receptor S1PR3 inhibit the phosphorylation of YAP, promote the binding of YAP and cMYC, and finally enhance the transcription of recombinant phosphoglycerate mutase 1 (PGAM1), which is a significant enzyme in aerobic glycolysis.32 This evidence concerns the gene YAP1 and osteosarcoma.