Furthermore, through using N‐acetyl‐l‐tryptophan in mice with CCl4‐induced liver fibrosis, the TGF‐ β/Smad and Hippo/YAP signaling pathways were inhibited, and consequently, the expressions of α‐SMA and collagen I proteins were reduced, contributing to liver fibrosis improvement.265. The gene discussed is YAP1; the disease is Hepatic fibrosis.