Specifically, CAMs upregulated after PFO closure included Contactin 1 (CNTN1), Hemoglobin subunit Beta (HBB), Protein Tyrosine Phosphatase Receptor (PTPR) type C and SPARCL1 in right atrial blood, and Activated Leukocyte Cell Adhesion Molecule (ALCAM), Cadherin 1 (CDH1), PTPR type F, Collagen Type XIV Alpha 1 Chain (COL14A1), Talin 2 (TLN2), Adenosine Deaminase RNA Specific B1 (ADARB1), Zyxin (ZYX), Fibulin 5 (FBLN5), and Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1) in peripheral blood. The gene discussed is HBB; the disease is Patent foramen ovale.