For example, LA reduced ROS-induced eNOS suppression in the aorta in a rat model of hypertension-ischemia injury (Hsieh et al., 2018); improved endothelial function by increasing eNOS expression and acetylcholine (ACh)-induced vasorelaxation in the aortas of diabetic rats (Shin et al., 2018); and increased NO and decreased MMP-9 expression, a key marker of BBB disruption, under conditions mimicking Ca2+-related ischemic injury in a mouse brain endothelial cell line (Hsieh et al., 2021). The gene discussed is NOS3; the disease is hypertensive disorder.