Lobos-González et al. discovered that high level of caveolin-1 expression promotes the invasion and metastasis of melanoma (Lobos-González et al., 2013), Seker et al. discovered that overexpression of caveolin reduced the survival time of patients with gastric cancer (Seker et al., 2017), and Huang et al. indicated that increased expression of caveolin-1 causes malignant transformation of glioma cells (Huang et al., 2018). This evidence concerns the gene CAV1 and central nervous system cancer.