Goetz et al. reported that microenvironment remodeling by caveolin-1 fibroblasts leads to the migration and invasion of cancer cells (Goetz Jacky et al., 2011), Yamao et al. found that downregulated caveolin-1 expression reduces the invasiveness of pancreatic cancer cells (Yamao et al., 2019), and Shimizu et al. discovered that caveolin-1 fibroblasts could induce the growth and metastasis of tumor cells in lung cancer (Shimizu et al., 2017). This evidence concerns the gene CAV1 and lung carcinoma.