TP53 and cancer: This may not occur in cancers that inactivate p53, a common event that precedes WGD during cancer evolution (Bielski et al., 2018), although there are other biological alterations associated with tetraploidy and aneuploidy that can lead to metabolic and oxidative stress (Biczowa et al., 1968; Anatskaya and Vinogradov, 2007; Li et al., 2010; Stingele et al., 2012; Shaukat et al., 2015; Newman et al., 2019).