ACSL4 and acute kidney injury: It has been reported that augmenter of liver regeneration could regulate the development of ferroptosis through GSH/GPX4; ACSL4 knockout significantly inhibited the ferroptosis of renal tubular epithelial cells in AKI mice; and XJB-5-131, a new generation of antioxidant, could specifically inhibit ferroptosis by inhibiting lipid peroxidation and then alleviate AKI (Zhao et al., 2020; Feng et al., 2022; Wang et al., 2022).