Furthermore, synergistic growth inhibition in hypoxic osteosarcoma has been achieved by the induction of ferroptosis and substantial GPX4 downregulation using ultrasound-activated doxorubicin (DOX)-Fe(VI)@HMS-HE-PEG (DFHHP) nanoparticles (Fu J. et al., 2021). The gene discussed is GPX4; the disease is osteosarcoma.