The expression of NEAT1 is significantly upregulated in SARS-CoV-2 infection, and its antiviral response mechanisms may be referenced to its mechanisms in hantavirus infection, where NEAT1 relocated splicing factor proline- and glutamine-rich protein (SFPQ) from the potential promoter regions of several antiviral genes to the paraspeckles, removing the transcriptional inhibitory effects of SFPQ. The gene discussed is SFPQ; the disease is hantavirus infectious disease.