TP53 and adenocarcinoma: When APC and TP53 are mutated in intestinal stem cells, a large number of aneuploidy cells can be found through the construction of organoid model, it was found that the organoids could develop into adenocarcinoma after tumor organoids transplanted into immunodeficient mice, this suggested that APC and TP53 gene mutations took an important driving role in the development of colorectal carcinogenesis.