ADCY1 and Duchenne muscular dystrophy: Although TSHR is not differentially expressed between VL and TA in our study, “Adenylate Cyclase-Activating G Protein-Coupled Receptor Signaling Pathway” trended toward significance among the biological process GO terms (p = 9.92E-02), with 16 of the 17 genes higher in the TA (data not shown), suggesting a protective role in the TA and consistent with the proposed therapeutic relevance of upregulation of adenylate cyclase in DMD, where adenylate cyclase activation stimulates TSHR signaling, reduces muscle stem cell senescence and improves their proliferation (Taglietti et al., 2023).