DMD encodes dystrophin, which plays a critical structural role in skeletal and cardiac muscle fibers by linking the intra-myofiber F-actin of the Z-disk to the extracellular matrix through binding components of the dystrophin-associated glycoprotein complex at the muscle membrane (Hoffman et al., 1987; Way et al., 1992). This evidence concerns the gene DMD and Duchenne muscular dystrophy.