The TRPV6 cation channel is highly selective for Ca2+, with PCa/PNa values greater than 100, playing a crucial role in calcium homeostasis in various cell types (Bödding and Flockerzi, 2004), making this channel closely involved in intracellular Ca2+-related pathways and in bone mineralization (Lehen’kyi et al., 2007; Ma et al., 2020). Here, TRPV6 is linked to posterior cortical atrophy.