MMP9 and neuroendocrine neoplasm: Previous studies have reported that a knockdown of TRPV6 in hormone-sensitive LNCaP cells decreased the proliferation, accompanied by a decrease in the activation of the nuclear factor of activated T cells (NFAT), whereas in neuroendocrine tumors (Lehen’kyi et al., 2007; Skrzypski et al., 2016), it decreased the migration and invasion through matrix metalloproteinase 9 (MMP9) and cathepsin B (Kim et al., 2021) and decreased cell survival and resistance to chemotherapy (Raphaël et al., 2014).