Previous studies have suggested that TRPV6 could play a role in the acquisition of an aggressive phenotype, having a role in the migration, invasion, and metastasis of the pancreas, colorectal, breast, and the prostate cancer cells including osteoblastic lesions (Raphaël et al., 2014; Song et al., 2018; Arbabian et al., 2020; Ozaki et al., 2022). This evidence concerns the gene TRPV6 and Familial prostate cancer.