Currently, only a few channels of the TRP family have been characterized as having a role in tumor angiogenesis, such as TRPV4, TRPV3, TRPM3, and TRPA1, demonstrated in lung carcinoma, renal cell carcinoma, cancer-associated fibroblast, and prostate cancers (Derouiche et al., 2017; Vancauwenberghe et al., 2017; Li et al., 2020; Kanugula et al., 2021; Li et al., 2022; Wei et al., 2022). The gene discussed is TRPV4; the disease is hereditary clear cell renal cell carcinoma.