As a hypoxia gene, STC1 is also an intracellular protein that can bind to mitochondrial receptors, increase mitochondrial oxidative phosphorylation (OXPHOS), and play an important role in epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) formation (Ellard et al., 2007; Zhang et al., 2000; Abe et al., 2021). This evidence concerns the gene STC1 and cancer.