Verdura et al. reported that resveratrol can inhibit glyco-PD-L1-processing enzymes (α-glucosidase/α-mannosidase) that modulate N-linked glycan decoration of PD-L1, thereby promoting the endoplasmic reticulum retention of a mannose-rich, abnormally glycosylated form of PD-L1, ultimately impeding its targeting to the cancer cell membrane and promoting immunity 95. Here, CD274 is linked to cancer.