Many lines of evidence demonstrate that curcumin inhibits tumor progression by modulating multiple pathways (e.g., NF-κB, MAPK, STAT3; 99), coordinating tumor suppressor factors (e.g., P53, cytokines IL-1, -2, -6, -8, or -12, IFN-γ) to promote cancer cell apoptosis and clearance 100, 101, and inhibiting angiogenesis 102. This evidence concerns the gene TP53 and neoplasm.